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No Title Journal First author Year WoS database total cited Times Cited in All Databases AS 1 Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline The Journal of Clinical Endocrinology & Metabolism Legro, Richard S 2013 882 973 121 2 Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications Endocrine Reviews  Diamanti-Kandarakis, Evanthia 2012 862 920 46 3 Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertility and Sterility  Fauser, Bart CJM 2012 854 926 58 4 The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis Human Reproduction  Bozdag, Gurkan 2016 492 527 25 5 Epidemiology, diagnosis, and management of polycystic ovary syndrome Clinical Epidemiology Sirmans, Susan M. 2014 478 506 157 6 Polycystic ovary syndrome Nature Reviews Disease primers  Azziz, Ricardo 2016 464 478 72 7 The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocrine Reviews  Rosenfield, Robert L. 2016 440 470 43 8 Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology Escobar-Morreale, Héctor F 2018 436 476 44 9 Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis Human Reproduction  Lim, Siew S. 2012 382 414 20 10 Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome Endocrine Reviews  Dumesic, Daniel A 2015 378 407 98 11 Criteria, prevalence, and phenotypes of polycystic ovary syndrome Fertility and Sterility  Lizneva, Daria 2016 362 400 65 12 Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic–hyperinsulaemic clamp Human Reproduction  Stepto, Nigel K. 2013 362 388 25 13 Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome Nature Genetics  Shi, Yongyong 2012 359 383 5 14 Fresh versus frozen embryos for infertility in the polycystic ovary syndrome New England Journal of Medicine  Chen, Zi-Jiang 2016 351 395 281 15 Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria Human Reproduction  Yildiz, Bulent Okan 2012 346 368 5 16 Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome Human Reproduction  Teede, Helena J. 2018 334 359 60 17 The polycystic ovary syndrome: a position statement from the European Society of Endocrinology European Journal of Endocrinology Conway, Gerard 2014 332 377 9 18 Letrozole versus clomiphene for infertility in the polycystic ovary syndrome New England Journal of Medicine  Legro, Richard S 2014 290 319 283 19 Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis Human Reproduction Update  Murri, Mora 2013 268 281 5 20 The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis Obesity Reviews  Lim, S. S. 2013 265 287 28 21 Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society Human Reproduction Update  Dewailly, Didier 2014 243 266 6 22 Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society. Human Reproduction Update  Escobar-Morreale, H. F. 2012 241 260 9 23 Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis Human Reproduction Update  Barry, John A 2014 234 248 43 24 Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database of Systematic Reviews  Tang, Thomas 2012 232 236 0 25 Pregnancy complications in women with polycystic ovary syndrome Human Reproduction Update  Palomba, Stefano 2015 225 241 12 26 The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Human Reproduction Update  Balen, Adam H. 2016 223 246 38 27 Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction Steroids González, Frank 2012 263 262 17 28 Prevalence of polycystic ovary syndrome in women in China: a large community-based study Human Reproduction  Li, Rong 2013 214 304 0 29 American Association of Clinical Endocrinologists, American College of Endocrinology, and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome-part 1. Endocrine Practice Goodman, Neil F., 2015 212 258 33 30 American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome-part 2. Endocrine Practice Goodman, Neil F., 2015 204 230 6 31 Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo The Journal of Clinical Endocrinology & Metabolism Sang, Qing 2013 203 226 7 32 Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations Nature communications Hayes, M. Geoffrey 2015 202 210 70 33 Rodent models for human polycystic ovary syndrome Biology of reproduction Walters, Kirsty A 2012 201 211 2 34 High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis Human Reproduction  Cooney, Laura G. 2017 196 200 10 35 Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Human Reproduction Update  Dewailly, Didier 2016 194 207 1 36 The potential implications of a PCOS diagnosis on a woman’s long-term health using data linkage The Journal of Clinical Endocrinology & Metabolism Roger Hart 2015 189 203 67 37 Polycystic ovary syndrome New England Journal of Medicine  McCartney, Christopher R. 2016 188 205 157 38 Cardiometabolic aspects of the polycystic ovary syndrome. Endocrine Reviews  Randeva, Harpal S 2012 178 184 3 39 Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome Nature communications Day, Felix R 2015 172 177 136 40 Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione The Journal of Clinical Endocrinology & Metabolism O’Reilly, Michael W. 2014 172 185 15 41 Can anti-Müllerian hormone predict the diagnosis of polycystic ovary syndrome? A systematic review and meta-analysis of extracted data The Journal of Clinical Endocrinology & Metabolism Iliodromiti, Stamatina 2013 172 185 3 42 Longitudinal weight gain in women identified with polycystic ovary syndrome: results of an observational study in young women Obesity Teede, Helena J. 2013 170 183 35 43 Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis Human Reproduction Update  Naderpoor, Negar 2015 169 180 34 44 Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood Nature medicine Tata, Brooke 2018 168 177 415 45 miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance Diabetes Chen, Yen-Hao 2013 164 181 29 46 Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis Reproductive Biology and Endocrinology Qin, Jun Z. 2013 164 176 11 47 Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models Endocrinology Caldwell, A. S. L 2014 160 172 0 48 Is PCOS an inflammatory process? Fertility and Sterility  Duleba, Antoni J. 2012 159 165 16 49 Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome Reproduction Spritzer, Poli Mara 2015 158 174 2 50 Vitamin D in the aetiology and management of polycystic ovary syndrome. Clinical endocrinology Thomson, Rebecca L. 2012 156 169 8 51 The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Müllerian hormone. Human Reproduction  Lauritsen, M. P. 2014 152 167 15 52 Genetic, hormonal and metabolic aspects of PCOS: an update Reproductive Biology and Endocrinology De Leo, V. 2016 151 165 10 53 Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome. Nature medicine Qi, Xinyu 2019 149 166 136 54 Sheep models of polycystic ovary syndrome phenotype Molecular and cellular endocrinology Padmanabhan, Vasantha 2013 146 149 3 55 Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria PLoS genetics Day, Felix 2018 145 148 218 56 Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance The Journal of Clinical Endocrinology & Metabolism Jones, Helen 2012 141 147 8 57 Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study Diabetes Gambineri, Alessandra 2012 141 146 62 58 Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic–hyperinsulinaemic clamp studies Human Reproduction  Cassar, Samantha 2016 139 149 2 59 The diagnosis of polycystic ovary syndrome during adolescence Hormone research in paediatrics Witchel, Selma F. 2015 136 141 10 60 An international consortium update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence Hormone research in paediatrics Ibáñez, Lourdes 2017 135 141 21 61 Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome The Journal of Clinical Endocrinology & Metabolism Moghetti, Paolo 2013 135 138 2 62 Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome The Journal of Clinical Endocrinology & Metabolism Gibson-Helm, Melanie 2017 129 133 322 63 Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts Journal of medical genetics Goodarzi, Mark O 2012 127 135 4 64 Dysbiosis of gut microbiota associated with clinical parameters in polycystic ovary syndrome  Frontiers in Microbiology Liu, Rui 2017 126 144 17 65 Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): a pilot study. PloS one Lindheim, Lisa 2017 126 153 48 66 11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome The Journal of Clinical Endocrinology & Metabolism O’Reilly, Michael W. 2017 125 126 25 67 Metabolic risk in PCOS: phenotype and adiposity impact. Trends in Endocrinology & Metabolism Moran, Lisa J 2015 124 133 3 68 Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial The Journal of Clinical Endocrinology & Metabolism Morin-Papunen, Laure 2012 123 133 9 69 Polycystic Ovary Syndrome Obstetrics & Gynecology Azziz, Ricardo MD, MPH 2018 120 134 8 70 The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis Oncotarget Ding, Tao 2017 120 134 24 71 Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype Proceedings of the National Academy of Sciences of the United States of America McAllister, Jan M. 2014 120 150 28 72 Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? Fertility and Sterility  Daan, Nadine MP 2014 120 131 10 73 Evaluating the association between endometrial cancer and polycystic ovary syndrome Human Reproduction  Haoula, Zeina 2012 119 133 7 74 Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy Journal of steroid biochemistry and molecular biology Patel, S 2018 118 126 5 75 Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility Cochrane Database of Systematic Reviews  Morley, Lara C. 2017 118 124 0 76 Placental steroidogenesis in pregnant women with polycystic ovary syndrome European Journal of Obstetrics & Gynecology and Reproductive Biology Maliqueo, Manuel 2013 117 120 0 77 Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome Journal of assisted reproduction and genetics Roth, Lauren W 2014 115 127 6 78 Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis BMC medicine Zhao, Yue 2012 115 127 11 79 Roles of oxidative stress in polycystic ovary syndrome and cancers Oxidative medicine and cellular longevity Zuo, Tao 2016 114 123 1 80 Lifestyle modification programs in polycystic ovary syndrome: systematic review and meta-analysis The Journal of Clinical Endocrinology & Metabolism Domecq, Juan Pablo 2013 113 118 3 81 Cancer risk and PCOS Steroids Dumesic, Daniel A. 2013 113 124 33 82 Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines Journal of the Academy of Nutrition and Dietetics Moran, Lisa J. 2013 113 116 106 83 Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies Human Reproduction Update  Veltman-Verhulst, Susanne M. 2012 112 113 9 84 Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression The Journal of Clinical Endocrinology & Metabolism Murri, Mora 2013 111 118 3 85 Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.”  Gynecological Endocrinology Unfer, Vittorio 2012 111 120 8 86 Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression Human Reproduction Update  Kakoly, N. S. 2018 109 121 0   87 Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism The Journal of Clinical Endocrinology & Metabolism Torres, Pedro J. 2018 109 124 153 88 Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry The Journal of Clinical Endocrinology & Metabolism Welt, Corrine K 2012 108 115 1                 89 Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity International journal of environmental research and public health Wolf, Wendy M. 2018 107 108 118 90 Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome Proceedings of the National Academy of Sciences of the United States of America Moore, Aleisha M. 2015 107 110 4 91 Reproductive and Metabolic Phenotype of a Mouse Model of PCOS Endocrinology Leonie, E. 2012 107 107 3 92 Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis Human Reproduction Update  Meyer, Michelle L. 2012 106 109 8 93 Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis Nutrients He, Chunla 2015 104 113 17 94 Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis Fertility and Sterility  Dokras, Anuja 2012 104 117 42 95 Association between polycystic ovary syndrome and the risk of pregnancy complications Medicine Yu, Hai-Feng 2016 103 107 4 96 Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome Medical hypotheses Tremellen, Kelton 2012 103 127 30 97 In vitro maturation as an alternative to standard in vitro fertilization for patients diagnosed with polycystic ovaries: a comparative analysis of fresh, frozen and cumulative cycle outcomes Human Reproduction  Walls, M. L. 2015 102 105 25 98 In vitro maturation or in vitro fertilization for women with polycystic ovaries? A case–control study of 194 treatment cycles. Fertility and Sterility  Gremeau, Anne-Sophie 2012 102 104 56 99 Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome Cochrane Database of Systematic Reviews  Farquhar, Cindy 2012 102 108 0 100 Poly Cystic Ovarian Syndrome: An Updated Overview   Frontiers in physiology El Hayek, Samer 2016 100 110 15

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